We vaccinate the puppies at 6, 9, 12 weeks of age with Nobivac Canine 1 (DAPPv). We start vaccines when the puppies are 6 weeks of age because Northeastern Missouri has a high Parvo rate and the latest research and development has proven 6 weeks is when the maternal antibodies begin to diminish, leaving puppies vulnerable. The Nobivac vaccine is a 5-way modified live canine vaccine for protection against canine parvovirus (CPV), adenovirus type 1 (hepatitis) and type 2 (respiratory disease), parainfluenza, and canine distemper. Our dogs receive a booster every 5-7 years thereafter based on blood titer levels. Many vets will vaccinate annually and this is now found to be unnecessary AND unhealthy.

Note:  Some literature will recommend a fourth shot given between after 20 weeks to minimize risk of maternal antibody interference. Our Vet will administer the fourth vaccine at 24 weeks (when our puppies go in for their rabies vaccine).  The latest research and development has PROVEN that puppies continue to have maternal anitbodies until 20 weeks of age thus, it is imperitive, that the puppies receive a final shot at or after 20 weeks of age in order to be completely vaccinate. 

Parvo and Distemper kill more dogs than anything else and they are totally preventable. It is strongly recommended that you DO NOT allow your puppy to socialize with other dogs outside until they are at least 16-20 weeks old. This means do not allow the puppy outside on grass or other dirt where other unknown dogs have visited until their vaccine series has been completed.

Until their vaccine series is complete, DO NOT take the puppies to parks, shows or trials. If you are going to take them outside to socialize them, or to the Vet, carry them 100% of the time they are in a public setting outside or at the Vet's office until the vaccine series is complete. Do not take the puppies with you to the pet store as pet stores have all kinds of young (and sometimes sick) puppies running through them.

Puppies get their Rabies Vaccine at 20-24 weeks (new owner). 
Puppies will require a Rabies Booster no later within 1 year of initial dose regardless of age at time of initial dose, then every 3 years thereafter as required by law.

I am a big fan or Terrierman's Blog.  Patrick Burns is a world renowned breeder of Jack Russel Terriers and has done extensive research in canine health including  vaccines, intestinal worms, heartworms and antibiotic treatments for canines. Better yet, he freely shares all of this research in his blog. I am not going to re-write his      blog here but rather provide you with the link to his site because KNOWLEDGE IS POWER!  Do your own research and discuss your pet's care with your Veterinarian.

Intestinal Worm Treatment

We worm the puppies at 2, 4, 6 & 8 weeks of age with Pyrantel Pamoate. Our Vet recommends the puppies be de-wormed every 2 weeks for 8 weeks or 4 times.  Starting monthly heartworm prevention, with Pyrantel added, at 10 weeks of age will ensure ongoing monthly protection.

Our adult dogs receive Ivermectin with Pyrantel every month as part of their Heartworm prevention. The adult dogs also receive an annual de-worming with the use of Fenbendazole, which kills all canine worms.

Heartworm Treatment

We treat our dogs monthly with Tri-Heart Plus. It contains both Ivermectin and Pyrantel so it is effective against heartworms and intestinal worms! No matter what brand you use, you can set up email reminders here: This site will send you an email so you never forget to administer the monthly dose. Puppies can start as early as 6 weeks but our Vet recommends waiting until 10 weeks (puppies are already receiving the Pyrantel Pamoate and he doesn’t advise administering the same medication, in different forms, which could overdose a small puppy). 

Flea and Tick Prevention

We treat our dogs with Fiproguard Flea & Tick squeeze-on monthly the same date they are given their heartworm preventative ONLY IF THEY NEED IT...we do not dose our dogs year round with these chemicals. We do not have a flea problem, however, if one should arise we would first treat with food grade Diatomaceous Earth (D.E.). 

Fiproguard is the generic (and much cheaper) version of Frontline’s Top spot (and works just as good). Wolf Creek Ranch has shared extensive information about D.E. and we highly recommend that you use this non-poisonous and effective treatment before reaching for the chemical treatment of fleas and ticks.

Puppy Nutrition

We believe that providing the highest quality nutrition is paramount in the growth and development of our puppies. We feed, and recommend, only premium adult and puppy formulas. We raise our puppies and breeding dogs on ProPac Ultimates. It is a NATURAL, Large Breed puppy formula made by Midwestern Pet Foods, which can be purchased at online pet stores and local Tractor Supply stores. ProPac Ultimates is a No Corn, No Wheat, No Soy dry dog food that has ideal Carbohydrate and Fat levels for optimal nutrition, growth and development. The puppies are fed ProPac Ultimates Large Breed puppy formula because it contains the proper Calcium & Phosphorus ratio to help large breed puppies avoid growth issues such as Hip Dysplasia, Elbow Dysplasia and Panosteitis (Pano). Our adult LGDs are fed Wholesomes Large Breed formula. The adults receive a combination of both Wholesomes and the Large Breed puppy formula during the cold winter months.

Great Pyrenees puppies grow exponentially in the first 12 months (it takes a human 18 years to reach full stature) and puppy owners who feed excess carbohydrates and calcium end up with a dog with developmental orthopedic disease (DOD). DOD describes a group of diseases that can occur during growth and development, the most familiar being Hip Dysplasia. The latest Research and Development indicates that a puppy diet with excess Carbohydrates, Calcium and Phosphorus is the contributing factor for developmental orthopedic disease. For this reason, large breed puppies should be fed a Large Breed puppy formula until 18 months of age (when the growth plates close). Many Vets and Breeders still suggest changing puppies to Adult or All Stages formulas to avoid "fast" growth. This has now been found to be detrimental to their growing bones!

In the past, commercial diets for puppies were marketed with no distinction or formulation differences considering the mature dogs' size. These diets were nutrient-dense, high-energy foods designed to actually encourage maximum growth, which is now known to be the
primary risk factor for DOD. Today, many dog food companies offer diets formulated for large breed puppies, with energy density, calcium and phosphorus levels that are lower than those of standard puppy feeds. These diets are what owners of large breed puppies should be feeding to help avoid developmental diseases.

We send home a bag of dog food to mix with the brand you will purchase to help transition over to their new food. Your puppy will need to eat three times a day. Around six months of age they will eat only twice a day and then eventually taper off to once a day. We recommend that you do NOT allow your puppy free-choice food at all times.
Research has shown that over-nutrition of large breed puppies, during their rapid growth phase, can result in developmental orthopedic disease (DOD). 

These puppies are genetically programmed to grow to a certain height and length…it is determined by their DNA. Allowing your puppy to eat free-choice can lead to over-nutrition which can potentiate developmental and health disorders. For optimum bone and joint development, never supplement your puppy's diet with calcium. Research has proven that excess dietary calcium negatively influences skeletal development in large breed puppies. Feeding the right portion of carbohydrates, fat, calcium and phosphorus at scheduled intervals will ensure optimal growth and development of your puppy.

Here is a great video by Dr. Karen Becker that sums it all up:

The vast majority of commercial dog foods contain multiple GMO grains, fillers and preservatives which do nothing to benefit your puppy. We urge you to familiarize yourself with following website

Lastly, we highly recommend NuVet Plus Immune System Builder to all of our puppy buyers.  NuVet Plus helps to support the puppy’s still maturing immune system which will help protect them from a variety of health issues caused by free radicals, including allergies, skin & coat issues, ear infections and more. NuVet Plus is not just a vitamin. It’s an Immune System Builder with a precise balance of vitamins, minerals, omega fatty acids, amino acids and high-potency antioxidants. NuVet Plus protects against dangerous toxins and other harmful substances that pets encounter daily in the environment and in foods (many of which contain hormones, preservatives, meat by-products, pesticide residue, sugar, and allergens like corn and grain). NuVet products help put pets on the “path to perfect health” and support their development through every stage in life.
While all quality dog foods will provide everything needed to sustain life, virtually all of them are cooked during the manufacturing process. The heat from cooking causes much of the nutrients to be lost during the process. NuVet Plus is cold processed allowing all of the benefits of its rich nutrients to be retained, giving your new puppy an extra layer of protection, especially during the most critical first year of life.
All of our dogs receive NuVet Plus and our puppies are started on NuVet Plus before they go home.  To encourage our puppy buyers to continue giving their new puppy NuVet, we will extend the terms and conditions of our Puppy Health Guarantee to 5 years if your new puppy is given NuVet Plus daily, as recommended by the manufacturer, starting as soon as you bring your new puppy home.

Call to Order 1-800-474-7044. Please use order code #29485 and ask for autoship for a 15% savings. Using the order code #29485 provides you up to 50% off what most Veterinarians charge and enables us to verify that the puppy is receiving the NuVet Plus supplement so that we can extend the Puppy Health Guarantee to 5 years. We are very passionate about our Pyrs and our goal is to Help Increase Your Pet's Longevity and Quality of Life!

Health Information

A Veterinarian is a great resource for dog care. The following information on medication and nutrition is for your information only and it's best to follow your Veterinarian's advice on all dog care issues. New puppy owners will receive a vaccine and worming record so your puppy’s Veterinarian will know where the puppy is at in the vaccine series. Always check with your Veterinarian for advice on all medications and nutrition.

The following information is offered based on how we treat our dogs. For more detailed information, discuss your puppy's care with his Veterinarian.